Representative photomicrographs (HE stain) of mouse pancreas in low power (a, b) and high power (c, d) after 48 h of sham operation (S) or PD ligation. PD ligation resulted in acute pancreatitis characterized by edema, intense leukocytic infiltration, vascular congestion and hemorrhage. Graphs show pancreatic PMN count (e) and edema score (f) of the HE-stained slides. At 48 h, only the PD ligation group had evidence of acute pancreatitis while sham and BD-ligated groups did not (means ± SEM; * p < 0.05 vs. sham and BD ligation groups; n ≥ 10/group).