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. 2010 Oct 29;10(5):565–579. doi: 10.1159/000317254

Fig. 2.

Fig. 2

Effect of TMZ and BG on the growth and mitotic and apoptotic indices of pancreatic cell lines Capan-1 (mut p53) and Capan-2 (wt-p53). a Induced apoptosis in Capan-1 and Capan-2 cells in response to BG/TMZ treatment. Cells were treated with 0–1,000 μM TMZ plus 30 μM BG and subjected to TUNEL analysis at 48 h after treatment. Bars depict the average from 2 independent experiments ± standard error of 5 measurements per sample. b Effects of TMZ and BG on growth and mitotic and apoptotic indices. Cells were untreated or treated with PEG (continuously; control for BG), BG (30 μM; continuously), DMSO (30 min; control for TMZ), TMZ (30 min with 250 μM), or BG + TMZ (30 min with 30/250 μM). The total number of cells and the number of apoptotic/mitotic cells were determined at 48 and 96 h after treatment. Apoptotic/mitotic indices are defined as the number of apoptotic/mitotic bodies counted per 1,000 cells, respectively. Bars depict the average from 2 independent experiments ± standard error of 5 measurements per sample. UT = Untreated.