Fig. 1.

a, b Normal glomeruli and tubules in the sham WT and the l-NAME-treated WT. c Two glomeruli with significant mesangial matrix expansion (MM expansion) in the 7NI-treated WT. d An area of focal tubulointerstitial fibrosis and inflammation in the WT mice subjected to cautery/nephrectomy (CN). e Significant glomerular sclerosis in WT mouse with CN and given l-NAME. f Global MM expansion in the upper glomerulus and an obsolescent glomerulus, below. g Obsolescent glomerulus in the eNOS knockout sham. h An obsolescent glomerulus and a normal glomerulus with MM expansion in the eNOS knockout with CN.