Table 3.
Genotype distributions of the SMAD4 tSNPs in gastric cancer cases and controls and risk estimates n (%)
| SNP No. | SNP ID | Genotypes | Cases (n = 322) | Controls (n = 351)1 | P value (2df)2 | Crude OR (95% CI) | Adjusted OR (95% CI)3 |
| 1 | rs12958604 | AA | 99 (30.8) | 106 (30.5) | 0.961 | 1.00 | 1.00 |
| AG | 155 (48.1) | 171 (49.1) | 0.97 (0.68-1.38) | 0.98 (0.69-1.39) | |||
| GG | 68 (21.1) | 71 (20.4) | 1.03 (0.67-1.59) | 1.01 (0.66-1.56) | |||
| 2 | rs10502913 | GG | 164 (51.0) | 162 (46.4) | 0.505 | 1.00 | 1.00 |
| GA | 136 (42.2) | 161 (46.1) | 0.83 (0.61-1.14) | 0.86 (0.63-1.18) | |||
| AA | 22 (6.8) | 26 (7.5) | 0.84 (0.46-1.54) | 0.81 (0.44-1.49) | |||
| 3 | rs17663887 | TT | 307 (95.3) | 311 (88.6) | < 0.001 | 1.00 | 1.00 |
| TC | 15 (4.7) | 40 (11.4) | 0.38 (0.21-0.70) | 0.38 (0.21-0.71) | |||
| 4 | rs9304407 | GG | 85 (26.4) | 112 (31.9) | 0.291 | 1.00 | 1.00 |
| GC | 179 (55.6) | 181 (51.6) | 1.30 (0.92-1.85) | 1.32 (0.93-1.87) | |||
| CC | 58 (18.0) | 58 (16.5) | 1.32 (0.83-2.09) | 1.29 (0.81-2.05) | |||
| 5 | rs12456284 | AA | 149 (46.3) | 143 (40.7) | 0.003 | 1.00 | 1.00 |
| AG | 160 (49.7) | 170 (48.4) | 0.90 (0.66-1.24) | 0.90 (0.66-1.24) | |||
| GG | 13 (4.0) | 38 (10.8) | 0.33 (0.17-0.64) | 0.31 (0.16-0.60) |
1
No. of subjects in controls (n = 348 for SNP1, n = 349 for SNP2) were less than the total number (n = 351) because some DNA could not be genotyped;
2
Two-sided χ2 test for the frequency distribution;
3
Adjusted for age, sex, smoking status, and alcohol use. SNP: Single nucleotide polymorphism; OR: Odds ratio; CI: Confidence interval.