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. 2010 Sep 14;59(12):3108–3116. doi: 10.2337/db09-1886

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© 2010 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 3. — dsAAV-expressed GLP-1 is localized to insulin-producing β-cells. Expression of GLP-1 in db/db mice treated with dsAAV–eGFP (A) and dsAAV–GLP1 (B) was examined by immunofluorescence at 14 weeks of age, or 10 weeks post-treatment. Islets from mice treated with dsAAV–GLP1 contained examples of β-cells (indicated by white arrows) that were positive for both GLP-1 (green) and insulin (red). Islets from mice treated with dsAAV–eGFP contained no examples of GLP-1 and insulin double-positive cells, indicating that the green staining observed in these samples is glucagon from pancreatic α-cells. Data are representative of at least two sections per mouse, n = 10 mice per group. Scale bar = 100 μm in all images. (A high-quality digital representation of this figure is available in the online issue.)