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. 2010 Sep 17;59(12):3117–3126. doi: 10.2337/db09-1805

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© 2010 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 8. — HFD-fed RIPcre⁺ Pten^fl/fl and RIPcre⁺ Pten^fl/fl Lepr^db/db mice showed intact islet integrity and uncompromised response to gamma irradiation. A: Laminin and β-catenin staining demonstrated intact basement membrane and cell-to-cell adhesion in HFD-fed (9 months of age) RIPcre⁺ Pten^fl/fl (−/−) and RIPcre⁺ Pten^fl/fl Lepr^db/db (−/−; db/db) (9 months of age) mice. B: Transcripts levels of p53-related gene including Bax, Mdm2, and p21 during quantitative PCR of RIPcre⁺ Pten^+/+ (+/+) and RIPcre⁺ Pten^fl/fl islets with or without 30Gy gamma irradiation (n = 2). C: Western blotting (left panel) and quantification (right panel) of p-p53 (Ser392), total p53, cleaved MDM2, and total MDM2 in RIPcre⁺ Pten^+/+ and RIPcre⁺ Pten^fl/fl islets with or without 30Gy gamma irradiation (n = 2). *P < 0.05. Scale bar, 50 μm. Results are presented as mean ± SE. (A high-quality digital representation of this figure is available in the online issue.)