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. 2010 Sep 7;59(12):3159–3166. doi: 10.2337/db10-0365

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© 2010 by the American Diabetes Association.

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FIG. 7. — A: Graph shows the effect of LOX siRNA on LOX protein level in RRECs. In cells grown in HG medium and transfected with LOX siRNA, the LOX protein expression was significantly decreased compared with that in cells grown in HG medium and transfected with scrambled siRNA. Data are expressed as mean ± SD (*P < 0.005, **P < 0.05). B: Effect of reduced LOX activity on cell monolayer permeability and effect of reduced LOX expression on cell monolayer permeability. The permeability of FITC-conjugated dextran molecules was significantly decreased to near normal level in cells grown in HG medium after incubation with BAPN compared with RRECs grown in HG. Data are expressed as mean ± SD (*P < 0.05, n = 6; **P < 0.05; n = 6). The permeability of FITC-conjugated dextran molecules was also significantly decreased to near normal level in cells grown in HG medium after transfection with LOX siRNA compared with untransfected RRECs grown in HG. Data are expressed as mean ± SD (***P < 0.005; n = 3). N, normal.