TABLE 1.

Characteristics of control apoE^−/− mice, diabetic apoE^−/− mice, and diabetic apoE^−/− mice treated with D-4F

	Controls	Diabetic	Diabetic + D-4F
Total cholesterol (mg/dl)	493 ± 124	993 ± 521*	1,082 ± 417
LDL cholesterol (mg/dl)	467 ± 120	954 ± 526*	1,027 ± 410
HDL cholesterol (mg/dl)	18 ± 4	14 ± 4*	14 ± 3
Triglyceride (mg/dl)	41 ± 17	59 ± 65	62 ± 35
Glucose (mg/dl)	181 ± 32	366 ± 123*	420 ± 89
Insulin (pg/ml)	281 ± 113	132 ± 68*	181 ± 114
Weight (g)	20.1 ± 1.4	16.9 ± 3.7*	16.2 ± 2.6

Values are expressed as average ±SD. Mice were treated with 8 weeks of D-4F treatment in drinking water; 0.2 mg/ml as described in methods.

*P < 0.01 diabetic vs. control.