Skip to main content
. Author manuscript; available in PMC: 2010 Dec 7.
Published in final edited form as: Cell Stem Cell. 2009 Dec 4;5(6):634–645. doi: 10.1016/j.stem.2009.10.015

Figure 3. ApoE4 Impairs Dendritic Development of Newborn Neurons in the Hippocampus.

Figure 3

(A–G) Confocal three-dimensional reconstruction of dendrites (inverted images) of newborn neurons (4 weeks after retrovirus-GFP injection) in the dentate gyrus of wildtype (A), apoE3-KI (B), apoE4-KI (C), and apoE-KO (D) mice, wildtype mice treated with PB (E), apoE3-KI mice treated with PB (F), and apoE4-KI mice treated with PB (G). Scale bar, 50 µm.

(H–K) Total dendritic length (H, J) and dendritic branch number (I, K) of newborn neurons. * p < 0.05 (t test in H and I; Kolmogorov-Smirnov test in J and K). WT, n = 43; E3-KI, n = 84; E4-KI, n = 73; E-KO, n =35; WT + PB, n =52; E3-KI + PB, n =42; E4-KI + PB, n = 31. Values in panels H and I are mean ± SEM.