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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Exp Hematol. 2010 Aug 26;38(12):1131–1142.e1. doi: 10.1016/j.exphem.2010.08.003

Figure 8.

Figure 8

Representative confocal microscopic images documenting the expression of primitive markers in circulating very small embryonic like stem cells. The pluripotent nature of circulating VSELs is evidenced by the positivity for the primitive surface marker SSEA-4 (FITC, green) and the nuclear marker Oct-4 (TRITC, red). Circulating VSELs are negative for the expression of CD45 (Cy5, Magenta). Nuclei are stained with DAPI (blue). The merged image demonstrates the co-localization of Oct-4 in the nucleus and SSEA-4 on the surface. The scale indicates 5μm.