Figure 11.

Effects of a MEK inhibitor on glucose-induced insulin secretion in the presence of H₂O₂ and quercetin in INS-1 cells. INS-1 cells were incubated in the presence of 8.3 mmol·L⁻¹ glucose (G), and in the absence or presence of H₂O₂, quercetin (Q) and UO126 (MEK inhibitor) used at the concentrations indicated. Insulin secretion was quantified by the homogeneous time resolved fluorescence method. Data are expressed relative to the response obtained with 8.3 mmol·L⁻¹ glucose, taken as 100%. A multiple comparison analysis of data was performed. Bars with the same letter do not differ significantly (P > 0.05).