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Mean arterial plasma concentration–time profiles of itraconazole (A) and 7-hydroxyitraconazole (B) after single i.v. administration of itraconazole 20 mg·kg−1 in the absence and presence of metformin 100 mg·kg−1, and of metformin (C) after single i.v. administration of metformin 100 mg·kg−1 in the absence and presence of itraconazole 20 mg·kg−1 to rats. Symbols show means and bars represent SD.
