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Effect of aminoguanidine on uterine prostaglandin production in LPS-induced preterm labour. Three doses of aminoguanidine were administered (i.p., 6 mg) at 7, 13, and 19 h to control or LPS-treated female BALB/c on day 15 of pregnancy. Uterine strips were collected and the production of PGE2 and PGF2α was measured by RIA. aP < 0.001 versus day 15, bP < 0.01 versus day 15 + LPS. Values are expressed as means ± SEM (n ≥ 4). LPS, lipopolysaccharide.
