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Effects of synthetic APETx2 on ASIC3 current recorded in CHO cells. ASIC3 currents were recorded using whole-cell voltage clamp techniques. From a holding potential of −60 mV, currents were activated by lowering external pH to 5.5 in the absence or presence of 3 µM APETx2 peptide, or 3 µM of the control, linearized APETx2 peptide (A). Concentration–response curve for block of ASIC3 currents by APETx2 (B). Results were plotted as mean ± SD (n = 3).
