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Effects of i.t. administration of APETx2 in the CFA inflammatory pain model. Mechanical hypersensitivity was produced by injection of CFA into the left hind paw. Twenty-four hours after establishment of inflammation and hypersensitivity, APETx2 was administered by i.t. injection, and paw withdrawal thresholds were measured at different time intervals for the inflamed (A) and non-inflamed hind paw (B). Data are expressed as mean ± SEM.
