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(A) Hill slopes of 3,844 Category C aggregators vs. 228 of Category E reactive or problematic inhibitors vs. 493 Category G top detergent sensitive inhibitors. (B) qHTS detergent-free curve of an aggregator SID 17508642 (44) with a Hill slope of 4. (C) Detergent resistant inhibition curves of two reactive compounds, SID 50107106 (45) (steep Hill slope) and SID 14739064 (46) (Hill slope of 0.5). (D) Detergent resistant cruzain specific inhibitor SID 24406445 (47) with Hill slope of 1.
