Table 2.

Components of the Tennessee Children's Respiratory Initiative enrolment visit, and each follow‐up contact

	Enrolment	1–2‐year‐old well‐child follow‐up visit	Year 1–year 3	Year 4–year 5	Year 6 follow up
	0–12‐month‐old term, non‐low birth weight otherwise healthy infant enrolled at the time of a respiratory viral illness †	2‐year‐old well‐child visit conducted in the CRC or during home visit	Phone contact	Phone contact	Phone contact
Time line	Sept–May 2004–2008	2005–2009	2005–2011	2008–2012	2010–2014
Maternal skin testing ‡	✓
Questionnaire and chart review	✓
Administration of structured phone questionnaire				✓	✓
Infant nasal and throat swab for viral identification	✓
Infant urine specimen	✓
Family history, including detailed atopic history	✓
Infant nasal epithelium (for cell culture repository)		✓
Child serum IgE and allergen specific IgE determination		✓
Infant DNA	✓ (or)	✓
Maternal DNA	✓ (or)	✓
Routine phone/mailing contact		✓ Every 12–18 months	✓	✓	✓

^† These infant–mother dyads were recruited and enrolled at Vanderbilt Children's Hospital (VCH), VCH paediatric emergency department, and VCH paediatric acute care clinic.

^‡ Allergen specific IgE (Phadiatop) is performed if unable to perform prick skin testing or negative histamine/positive control.

CRC, Clinical Research Center; IgE, immunoglobulin E.