TABLE 2 .
Replication and transmission of NJ/15, TN/560, G1, and G2 (H1N1) influenza viruses in ferrets
| Virus | Animal group | Clinical signs | Virus detection | Seroconversion values (serum HI titer/neutralizing titer)d |
|||||
|---|---|---|---|---|---|---|---|---|---|
| Wt loss (%)a | Increase in temp (°C) (day of onset) | Peak virus titer (log10 TCID50/ml) (day of onset)b | Last day of sheddingc | NJ/15 | TN/560 | G1 | G2 | ||
| NJ/15 | Donors | 10.5 | 1.2 (2) | 5.6e (2) | 6 | 160/40 | </< | </< | 160/40 |
| Contacts | 4.5 | 0.9 (1) | 5.4 (3) | 9 | 160/20 | </< | </< | 240/40 | |
| TN/560 | Donors | 8.9 | 1.0 (1) | 6.7 (2) | 6 | </< | 320/120 | 320/1,280 | </< |
| Contacts | 2.0 | 0.6 (3) | 5.2 (3) | 7 | </< | 320/240 | 320/640 | </< | |
| G1 | Donors | 9.1 | 2.5 (2) | 7.2 (2) | 8 | </< | 160/20 | 640/2,560 | </< |
| Contacts | 2.2 | 1.3 (3) | 7.4° (3) | 9 | </< | 160/60 | 940/1,280 | </< | |
| G2 | Donors | 4.1 | 2.8 (2) | 6.1 (2) | 8 | 320/80 | </< | </< | 320/40 |
| Contacts | 2.5 | 1.0 (4) | 6.7 (3) | 9 | 640/200 | </< | </< | 640/180 | |
The maximum percent weight loss during the 21 days p.i.
Virus titer in nasal washes.
The first day of observation on which virus was not detected.
Hemagglutination inhibition (HI) antibody titers in ferret sera were determined at 21 days p.i.; values are expressed as reciprocals of serum that inhibited 4 hemagglutination units of H1N1 influenza virus. Neutralizing antibodies to H1N1 viruses (100 TCID50) were titrated in MDCK cells. Data (arithmetic mean titers) are shown for 1 ferret (for donors) or groups of 2 ferrets (for contacts). Homologous HI/neutralizing titers are shown in bold type. <, titer of <1:10.
P < 0.01 compared with the nasal wash virus titer for TN/560 virus (donors compared with donors and contacts with contacts; one-way ANOVA).