Table 1.
Radiochemical yield of [18F]3 and residual precursor amount using different precursors in the presence of different complex agents (n = 4, mean ± SD) *
| Time (min) |
[18F]KF/K222/K2CO3/DMSO | [18F]TBAF/ACN | |||
|---|---|---|---|---|---|
| 1 | 2 | 1 | 2 | ||
| [18F] 3 | 0 | 5.2 ± 2.5 | 4.2 ± 0.9 | 1.4 ± 0.8 | 1.3 ± 0.5 |
| 3 | 70.8 ± 7.5 | 53.0 ± 10.1 | 52.9 ± 6.7 | 35.6 ± 4.0 | |
| Radiochemical | 10 | 79.8 ± 5.3 | 70.0 ± 6.4 | 70.7 ± 4.7 | 54.8 ± 4.8 |
| Yield** (%) | |||||
| Residual | 0 | 100.0 ± 0.0 | 100.0 ± 0.0 | 100.0 ± 0.0 | 100.0 ± 0.0 |
| 3 | 76.9 ± 7.1 | 78.3 ± 4.7 | 59.0 ± 17.5 | 92.3 ± 2.3 | |
| precursor | 10 | 39.6 ± 10.9 | 36.6 ± 3.6 | 24.0 ± 9.7 | 72.4 ± 10.6 |
| amount(%) | |||||
*
Fluorination condition: 5.6 μmol precursor (either 1 or 2), 11.0 mg K222 and 2.0 mg K2CO3 or 21.5 mg TBAHCO3, 100 °C.
**
Radiochemical yield of [18F]3 was determined by TLC.