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(a) CHL reactive background T cells often demonstrate a range of specific reactive features including increased levels of CD2, CD5, CD7, and CD45 that are particularly noticeable on the CD4-positive T cells (red) compared to CD8-positive T cells (green). Also note increased CD4 : CD8 ratio among the T cells that is often, but not always, observed in CHL cases. (b) No such changes are seen in a patient with reactive follicular hyperplasia.
