Figure 5.

Protein kinase C (PKC) activity in tracheal epithelial cells of mice exposed to cigarette smoke. The vertical axis represents the mean (±SEM) of PKA activity in pmol/min/mg of ciliated tracheal epithelial tissue within each exposure group (n = 10). Smoke exposure for 6 to 12 months caused a significant (^#P < 0.05 and *P < 0.01, vs. time-matched controls.) increase in the particulate fraction levels of PKC activity. Smoke exposure for 9 to 12 months caused a significant (^#P < 0.05) decrease in the cytosolic fraction levels of PKC activity. This result indicates the activated translocation of the enzyme to the particulate fraction.