Figure 1.

Effects of nonselective S1P receptor agonist FTY720 on survival after bleomycin (Bleo) challenge. Mice received a single intratracheal (IT) dose of bleomycin (1.2 U/kg) or saline, and were treated with intraperitoneal vehicle or FTY720 at 5 or 0.5 mg/kg, three times per week, starting on Day 0. FTY720 treatment at both doses led to an increase in mortality within 2 weeks after bleomycin challenge. Data are combined from three independent experiments; n = 10–25 mice/group in total. For both FTY720 doses tested, P < 0.0001, comparing bleomycin + vehicle with bleomycin + FTY720 by log-rank test.