Figure 2.
Reversal effects of CYP2J2 gene delivery on right ventricular systolic pressure (RVSP) (A), right ventricle/left ventricle + septum (RV/LV + S) (B), mean systemic arterial pressure (mSAP) (C), and heart rate (D), and effects of NG-l-nitro-arginine methyl ester (l-NAME) on RVSP (E) and RV/LV + S (F). Hemodynamic measurements were performed 2 weeks after gene transfer, and results showed that CYP2J2 overexpression reversed the MCT-induced changes in RVSP and RVH, but had no effects on mSAP and heart rate. l-NAME attenuated the beneficial effect of CYP2J2 overexpression in the model of PAH induced by MCT. Data shown are mean ± SEM of 6–8 rats/group. *P < 0.05 versus control. #P < 0.05 versus MCT + pCB6.