Disruption of lamin A/C and lamin B localization by expression of a transfected US3 gene. Shown are digital merged images showing the localization of wild type US3, mutant US3, beta-galactosidase and lamin A/C or lamin B in Vero cells transfected with plasmids expressing US3 or beta-galactosidase protein. Green: lamins, blue: US3 or beta-galactosidase. For all panels A–L, Vero cells were transfected with a plasmid expressing wild-type or kinase dead US3 for 24, 48 and 72 h. For panels M and N, only the 72 h time point is shown. Time after transfection is indicated to the left of each row of panels. The proteins being detected are indicated above each column of panels.