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. Author manuscript; available in PMC: 2011 Nov 30.
Published in final edited form as: Respir Physiol Neurobiol. 2010 Aug 27;174(1-2):76–88. doi: 10.1016/j.resp.2010.08.017

Fig. 4. Genetic determination and genesis of 5-HT neurons.

Fig. 4

During the early embryogenesis 5-HT neurons are generated from ventricular zone precursors controlled by fibroblast growth factors 4 and 8 (Fgf4 and Fgf8) and sonic hedgehog (Shh). In post-mitotic neurons, a complex network of genes such as Pet1, Lmx1b, Nkx2.2, Mash1, Gata2, Gata3, and Phox2b will determine the important proteins for 5-HT biosynthesis and neurotransmission such as Tph, Aadc, SERT. (for details see Fig. 1).