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. Author manuscript; available in PMC: 2011 Nov 30.
Published in final edited form as: Respir Physiol Neurobiol. 2010 Aug 27;174(1-2):76–88. doi: 10.1016/j.resp.2010.08.017

Table 1.

Serotonin receptors found in the brainstem cardio-respiratory networks

subtype signalling cascades Physiological effects Localization cartdiorespiratory sites Central Function
5HT1A Gi/o proteins increase K+ conductance pre & post synaptic raphe nuclei
hypoglossal nuclei
ponto-medullary networks		 inhibit cell firing
depresses excitability of respiratory neurons
5HT1B* Gi/o proteins increase K+ conductance pre & post synaptic raphe nuclei inhibit cell firing
neurotransmitter release control
5HT1D Gi/o proteins increase K+ conductance axon terminals of both 5HT and non-5HT neurons dorsal raphe midbrain PAG behavioral breathing control?
5HT1E/1F Gi/o proteins unknown unidentified unidentified not known
5HT2A/2B/2C GQ/11 proteins decrease K+ conductance unidentified ponto-medullary networks (2A/2B ) neuronal excitation
5HT3 ionotropic Gating of K+, Na+ somato-dendritic/sub-cellular? NTS
area prostrema
dorsal motor nucleus of vagus		 neuronal excitation
vomitting reflex
5HT4 G s proteins decrease K+ conductance post synaptic pre-Botzinger complex neuronal excitation
neurotransmitter release control
5HT5 G i/o or Gs proteins unknown unidentified unidentified not known
5HT6 Gs proteins unknown post synaptic in higher brain areas unidentified not known
5HT7 Gs proteins decrease K+ conductance unidentified dorsal raphe
pre-Botzinger complex		 neuronal excitation