Tables 4a, 4b and 4c.
Some contributions to pituitary research from the Regional Endocrinology and Diabetes Centre, Royal Victoria Hospital, Belfast, 1954–2009
| 4a |
|---|
| Growth Hormone |
| • Visual failure after external pituitary irradiation 1979 |
| • Controlled trial of hGH in adult deficiency 1992 |
| • Some limited efficacy of bromocriptine in acromegaly 1886 |
| • Early dose response studies of octreotide in acromegaly 1990, 1993 |
| • First case series of changing glucose tolerance and of gallstones after octreotide in acromegaly 1989 |
| • Efficacy of octreotide LAR in acromegaly 1999 |
| • Effect of Octreotide LAR on tumour size in acromegaly 2002 |
| • Effect of hGH on insulin resistance in hypopituitarism 2002 |
| • Long term efficacy of XRT in acromegaly 2009 |
| 4b |
|---|
| Cushing's Syndrome |
| • First E uropean series of bilateral adrenalectomy for CS 1954 |
| • Early description of CS secondary to a lung tumour (carcinoid type) 1957 |
| • Invasive pituitary tumor developing after adrenalectomy 1959 |
| • Cyclical CS |
| – 2 rhythms in the same patient 1985 |
| – First ever series of patients 1985 |
| – Importance in assessments after surgery 1992, 1999, 2005 |
| • Petrosal sinus sampling in the diagnosis of ACTH-dependent CS 1989, 1999, 2000 |
| • Assessment of remission of CS after pituitary Surgery 1995, 1996, 2005 |
| • SOM-230(pasireotide) in pituitary-dependent CS 2008 |
| 4c |
|---|
| Other Pituitary Disease Research |
| • Normal puberty and fertility with bromocriptine alone in prolactinoma 1987 |
| • Comparison of cabergoline and bromocriptine in prolactinoma 1984 |
| • Macroprolactinemia as an important cause of hyperprolactinemia 2001 |
| • Assessment of H -P - A axis after pituitary surgery |
| • Metyrapone and naloxone in H-P –A axis assessment 2000 |
| • Low dose vs. regular dose synacthen vs. Insulin hypoglycaemia response 2000 |
| • Early post-operative serum cortisolto predict need for long term steroids after pituitary surgery 2004 |