A: adult IGF1 exon 1 mRNA expression and H3K4 dimethylation and trimethylation of P1 on exon 1. Open bars represent AdLib/AdLib (control), solid bars represent FR/AdLib (FR during pregnancy), and hatched bars represent FR/FR (FR during pregnancy and lactation); a and b denote a significant difference between the adult groups AdLib/AdLib, FR/AdLib, and FR/FR, P < 0.05. B: adult IGF1 exon 2 mRNA expression and H3K4 dimethylation and trimethylation of P2 on exon 2. Open bars represent AdLib/AdLib (control), solid bars represent FR/AdLib (FR during pregnancy), and hatched bars represent FR/FR (FR during pregnancy and lactation); a and b denote a significant difference between the adult groups AdLib/AdLib, FR/AdLib, and FR/FR, P < 0.05.