Table 1.
Treatment | Age | IGF1 Exon 1 | IGF1A | IGF1 Exon 2 | IGF1B |
---|---|---|---|---|---|
AdLib | Newborn | 100 ± 8.8 | 100 ± 22.8 | 100 ± 9.9 | 100 ± 9.0 |
FR | Newborn | 84.3 ± 25.8 | 211.9 ± 98.5 | 64.8 ± 17.1 | 104 ± 30.7 |
AdLib/AdLib | Adult | 100 ± 9.6 | 100 ± 6.9 | 100 ± 8.8 | 100 ± 5.0 |
FR/AdLib | Adult | 149.3 ± 6.6 | 133.7 ± 5.3 | 146 ± 7.7 | 164.9 ± 6.3 |
FR/FR | Adult | 74.6 ± 8.3 | 99.3 ± 6.8 | 86.3 ± 8.3 | 146.8 ± 21.0 |
Values are means ± SE. mRNA expression of regions of IGF1 relative to GADPH is expressed as a percentage of expression levels of controls for the age group. The results are from newborns at 1 day of age of ad libitum-fed animals (AdLib, controls) vs. food-restricted pregnancy animals (FR), adults at 9 mo of age of AdLib/AdLib (control) vs. FR/AdLib (food-restricted pregnancy and AdLib lactation), and FR/FR (food-restricted pregnancy and lactation). * and † Differences between adult treatment groups, P < 0.05.