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Effect of dietary protein on average cell size in wild-type and CCK-null mice. Mice were fed the specified diet for 7 days. Nuclei were stained with 4,6-diamidino-2-phenylindole (DAPI) and quantitated with Metamorph software as detailed in methods. An increase in cell size leads to a decrease in nuclear density. N = 4 mice per group; **P < 0.01 compared with similar mice on a control diet as determined by 2-way ANOVA.
