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. Author manuscript; available in PMC: 2011 Nov 24.
Published in final edited form as: J Am Chem Soc. 2010 Nov 2;132(46):16403–16416. doi: 10.1021/ja105129p

Table 2.

Macrocyclization via Alkyne-Alkyne Coupling

graphic file with name nihms-250235-f0011.jpg (5)
Entry Solvent Yield
1 benzene 22% (44% brsm)
2 THF 23% (5 d)
3a toluene 56%
4b toluene 36% (57% brsm)
a)

on 3.2 mg scale

b)

on 45 mg scale