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Iberiotoxin failed to inhibit EDHF-mediated changes in SMC [Ca2+]i and dilatation induced by ACh. A and B: graphs showing reduction in SMC [Ca2+]i and vasodilation induced by ACh in arteries treated with l-NNA and indomethacin and preconstricted with 100 nM iberiotoxin and PE. *Significantly different at P < 0.05 (2-way repeated-measures ANOVA); n, no. of arteries tested.
