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. 2010 Sep 10;299(5):H1374–H1381. doi: 10.1152/ajpheart.00168.2010

Table 2.

LV hemodynamics 10 days after Dox injection in WT and CrmA Tg mice

	Vehicle	Dox	Dox + 4-AN
LVEDP, mmHg
WT	3.5 ± 1.1	7.1 ± 0.8^*	4.2 ± 0.5^†
CrmA	3.1 ± 0.3	7.1 ± 0.6^*	3.3 ± 0.5^†
LVSP, mmHg
WT	107.9 ± 2.2	91.24 ± 5.7^*	103.4 ± 3.8^†
CrmA	111.8 ± 3.2	82.3 ± 2.6^*	105.2 ± 6.6^†
dP/dt_max, mmHg/s
WT	8,693 ± 304	6,529 ± 715^*	8,102 ± 461^†
CrmA	8,896 ± 486	5,816 ± 1075^*	8,413 ± 265^†
dP/dt_min, mmHg/s
WT	7,282 ± 530	4,202 ± 480^*	6,914 ± 246^†
CrmA	6,945 ± 562	3,029 ± 548^*	6,026 ± 359^†
CO, ml/min
WT	5.0 ± 0.4	2.8 ± 0.2^*	4.8 ± 0.4^†
CrmA	5.2 ± 0.5	2.3 ± 0.1^*	4.4 ± 0.6^†
τ, ms
WT	12.4 ± 1.1	23.0 ± 4.0^*	13.6 ± 1.2^†
CrmA	11.5 ± 0.7	24.8 ± 2.3^*	14.0 ± 1.2^†

Values are means ± SE; n = 6 to 7 mice. τ, ventricular isovolumic relaxation time constant.

^*

P < 0.05, Dox vs. vehicle;

^†

P < 0.05, Dox vs. Dox + 4-amino-1,8-naphthalimide (4-AN).