Fig. 2.

Forearm blood flow (FBF) responses to ascorbic acid infusion and local inhibition of nitric oxide (NO) and prostaglandins (PGs). FBF is presented during rest and steady-state exercise (Ex). A: subjects in whom NO (l-NMMA) was inhibited before PG (ketorolac). B: subjects in whom PG inhibition occurred before NO inhibition. Respective drug infusions occurred as indicated. Ascorbic acid significantly increased FBF in both groups. Independent NO inhibition did cause a significant decrease in FBF, and subsequent PG inhibition had no further effect (A). Independent PG inhibition had no effect on FBF and combined PG-NO inhibition significantly attenuated FBF (A). *P < 0.05 vs. within-trial steady-state exercise condition. †P < 0.05 vs. previous trial resting condition. ‡P = 0.09 vs. previous trial resting condition.