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. 2010 Nov 19;5(11):e14063. doi: 10.1371/journal.pone.0014063

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Wang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Intestine of zebrafish. (B) Small intestine of mouse. (C) Duodenum of human. Upper and lower limits of the division frequency of stem cells in vivo (once to twice per day) define a range of the number of stem cells required to be present on each section of inter-villi pocket in zebrafish intestine. Reduction in cell proliferation would result in a bigger value of and thus a prolonged epithelium renewal cycle. That would be accompanied by less number of stem cells around. On the other hand, enhanced cell proliferation would result in a smaller value of and thus an accelerated epithelium renewal process, accompanied by an increase in stem cell population. That would be the case where hyperplasia or adenoma starts to develop.

Inline graphic — (A) Intestine of zebrafish. (B) Small intestine of mouse. (C) Duodenum of human. Upper and lower limits of the division frequency of stem cells in vivo (once to twice per day) define a range of the number of stem cells required to be present on each section of inter-villi pocket in zebrafish intestine. Reduction in cell proliferation would result in a bigger value of and thus a prolonged epithelium renewal cycle. That would be accompanied by less number of stem cells around. On the other hand, enhanced cell proliferation would result in a smaller value of and thus an accelerated epithelium renewal process, accompanied by an increase in stem cell population. That would be the case where hyperplasia or adenoma starts to develop.