TABLE 7.

Apparent cannabinoid CB₁ receptor-independent effects of cannabinoid receptor agonists on ion channels other than TRP channels

See Section III.F for references and further discussion.

Ion Channel and Effect	Endocannabinoid(s)?	Effective Concentration Range	Nonendogenous Cannabinoid Agonist(s)?	Effective Concentration Range
Current enhancement/activation
KCa (BK) K+	Yesa	Nanomolar or micromolar	Yesb	Nanomolar or micromolar
Voltage-gated Na+	No	Micromolar	Yes	Nanomolar
Inhibition
Ca2+ (native)	Yesc	Nanomolar or micromolar	Yesb	Micromolar
T-type Ca2+ (CaV3.1)	Yesc	Micromolar	Yes	Micromolar
T-type Ca2+ (CaV3.2)	Yesa,c	Nanomolar or micromolar	Yes	Micromolar
T-type Ca2+ (CaV3.3)	Yesc	Micromolar	Yes	Micromolar
T-type Ca2+ (native)	N.D.	N.D.	Yes	Micromolar
N-, P-, or P/Q-type Ca2+	Yesc	Micromolar	Yes	Micromolar
KATP K+	Yesc,d	Micromolar	Yesb	Micromolar
TASK-1 K+	Yesa,c	Nanomolar or micromolar	Yes	Nanomolarb or micromolar
TASK-3 K+	Yesc	Micromolar	Yesb	Micromolar
Voltage-gated K+ (KV)	Yesc	Nanomolar or micromolar	Yes	Nanomolarb or micromolar
Voltage-gated Na+	Yes	Micromolar	Yes	Micromolare
Radioligand binding (↓)
L-type Ca2+	Yesc,d	Micromolar	Yesb	Micromolar
KATP K+	Yesc,d	Micromolar	Yesb	Micromolar
Voltage-gated Na+	Yesd	Micromolar	Yesd	Micromolar

N.D., no data.

^aAnandamide but not 2-arachidonoyl glycerol.

^bOnly R-(+)-methanandamide.

^cAlso R-(+)-methanandamide.

^dMay target an allosteric site on this ion channel.

^eSlight enhancement of sodium currents has also been detected in response to 10 nM R-(+)-WIN55212 (section III.G.3.).