Figure 6.

Progressive decline in Morris water maze performance in A/T mice (inverted triangles) compared to aged-matched WT counterparts (circles). Young mice featured impaired acquisition during hidden-platform testing, but only a trend toward decline in memory retention during the probe trial. Significant probe trial deficits appeared in adult and old A/T mice. Error bars represent SEM (n = 8–16 mice/group). Comparisons to WT, *P < 0.05, **P < 0.01, ***P < 0.001 using two-way analysis of variance followed by Bonferroni posthoc test (latency curves) or using Student’s t-test (probe trial histograms).