Table 3.

Multivariate Cox Regression Analysis of Sox4 Nuclear Expression in 48 Cases of Metastatic Melanoma and 89 Cases of Primary Melanoma

Variable*	All primary and metastatic melanomas			High-risk melanomas (thickness > 1.5 mm)
	Relative risk	95% CI†	P value	Relative risk	95% CI†	P value
Overall survival
Sox4	1.571	0.924–2.673	0.095	1.904	1.078–3.362	0.026
Age	0.676	0.407–1.122	0.122	0.974	0.574–1.650	0.922
Sex	1.238	0.736–2.084	0.419	1.075	0.606–1.906	0.802
Disease-specific survival
Sox4	1.780	1.001–3.163	0.049	1.994	1.087–3.658	0.025
Age	1.780	0.540–1.662	0.850	1.337	0.753–2.373	0.320
Sex	1.100	0.618–1.958	0.744	1.011	0.547–1.870	0.970

^*Coding of variables: Sox4 nuclear staining was coded as 1 (negative-weak) and 2 (moderate-strong). Age was coded as 1 (≤58 years), and 2 (>58 years). Gender was coded as 1 (female) and 2 (male). 

^†CI: confidence interval.