Table 1.
Correlation Analysis between SNPs and Morphological Profiles
| Locus/SNP | Morphology | Genotypes | No | Yes | OR (95% CI) | P values |
|---|---|---|---|---|---|---|
| 8q24.21 | Crohn-like lymphocytic reaction | GG | 137 | 318 | 1 | |
| rs6983267 | GT | 284 | 492 | 0.75 (0.58–0.96) | 0.021 | |
| TT | 90 | 207 | 0.99 (0.72–1.36) | 0.955 | ||
| 9p24 | Necrosis | AA | 102 | 291 | 1 | |
| rs719725 | AC | 112 | 346 | 1.08 (0.79–1.48) | 0.615 | |
| CC | 47 | 83 | 0.62 (0.41–0.95) | 0.026 | ||
| 9p24 | Desmoplastic reaction | AA | 58 | 335 | 1 | |
| rs719725 | AC | 42 | 415 | 1.71 (1.12–2.61) | 0.012 | |
| CC | 29 | 102 | 0.61 (0.37–1.00) | 0.049 | ||
| 9p24 | Tumor infiltrating lymphocytes >30/10 high-power fields | AA | 459 | 146 | 1 | |
| rs719725 | AC | 576 | 146 | 0.89 (0.61–1.03) | 0.087 | |
| CC | 152 | 59 | 1.22 (0.86–1.74) | 0.269 | ||
| 9p24 | Budding | AA | 292 | 226 | 1 | |
| rs719725 | AC | 327 | 285 | 1.13 (0.89–1.43) | 0.323 | |
| CC | 120 | 58 | 0.62 (0.44–0.89) | 0.010 | ||
| 10p14 | Moderate or well differentiated | GG | 159 | 608 | 1 | |
| rs10795668 | GA | 179 | 506 | 0.74 (0.58–0.94) | 0.015 | |
| AA | 34 | 98 | 0.75 (0.49–1.16) | 0.194 | ||
| 14q22.2 | Crohn-like lymphocytic reaction | TT | 163 | 347 | 1 | |
| rs4444235 | TC | 229 | 495 | 1.02 (0.80–1.30) | 0.902 | |
| CC | 125 | 190 | 0.71 (0.53–0.96) | 0.024 | ||
| 19q13.1 | Desmoplastic reaction | CC | 105 | 741 | 1 | |
| rs10411210 | CT | 23 | 123 | 0.76 (0.46–1.24) | 0.266 | |
| TT | 4 | 5 | 0.18 (0.05–0.67) | 0.004 | ||
| 20p12.3 | Mucin production in >50% of the tumor | CC | 558 | 75 | 1 | |
| rs961253 | CA | 585 | 119 | 1.51 (1.11–2.07) | 0.009 | |
| AA | 192 | 44 | 1.71 (1.14–2.56) | 0.010 | ||
| 20p12.3 | Infiltrative | CC | 320 | 285 | 1 | |
| rs961253 | tumor margin | CA | 330 | 350 | 1.19 (0.96–1.48) | 0.118 |
| AA | 137 | 87 | 0.71 (0.52–0.98) | 0.034 |
Genotypes for each morphological parameter that was significant (P value <0.05; see Supplemental Appendix at http://ajp.amjpathol.org). Significant OR and P values are presented in bold. Yes: support for the morphological parameter; No: no support.