Table 3.
Multivariate Analysis* of Survival of Patients with Low-Grade Diffuse Glioma (WHO Grade II)
| Variable | Number of cases | Hazard ratio (95% confidence interval) | P value |
|---|---|---|---|
| Genetic alterations | |||
| TP53 mutation ± IDH1/2 mutation | 96 | 1 | |
| 1/19q loss ± IDH1/2 mutation | 107 | 0.563 (0.367–0.865) | P = 0.0087 |
| IDH1/2 mutation only | 42 | 0.778 (0.486–1.245) | P = 0.2955 |
| No alteration | 23 | 0.910 (0.474–1.749) | P = 0.7773 |
| TP53 mutation + | 111 | 1 | |
| TP53 mutation − | 157 | 0.518 (0.358–0.751) | P = 0.0005 |
| 1p/19q loss + | 112 | 1 | |
| 1p/19q loss − | 156 | 2.170 (1.454–3.240) | P = 0.0002 |
| IDH1/2 mutation + | 239 | 1 | |
| IDH1/2 mutation − | 29 | 1.047 (0.593–1.850) | P = 0.8737 |
| Histology | |||
| Diffuse astrocytoma | 130 | 1 | |
| Oligodendroglioma | 91 | 0.556 (0.369–0.837) | P = 0.0049 |
| Oligoastrocytoma | 47 | 0.704 (0.442–1.121) | P = 0.1389 |
*
After adjusting for age, sex, treatment (surgery or surgery followed by radiotherapy).