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. 2010 Dec;177(6):2694–2700. doi: 10.2353/ajpath.2010.100468

Figure 1.

Figure 1

Grade 1 astrocytomas are positive for APBs. A: Measurement of APBs in astrocytomas. APBs (indicated with an arrow) had co-localized PML (green) and telomere DNA (red) fluorescent signals in nuclei (not shown) on analysis of paraffin-embedded samples at ×630 magnification. The criteria for an APB-positive cell included at least two co-localized areas greater than 0.9 μm in size (profile, bottom). Scale bar = 20 μm. B: Distribution of APB measurements among grade (G) 1−4 astrocytomas. The percentage of APB-positive cells is plotted against tumor grade. The criteria for APB-positive tumors included APBs greater than 0.5% of cells, as indicated by a dashed line. The median APB measurement is represented with a solid horizontal bar.