Skip to main content
. 2010 Dec;177(6):2827–2836. doi: 10.2353/ajpath.2010.100368

Figure 4.

Figure 4

Recovery of ER morphology and chaperone levels in exocrine pancreas of Grp78+/− mice after HFD. A: Representative TEM of pancreatic acinar cells from mice after 12 weeks of HFD (n = 2 for each genotype). Lower panels demonstrate higher magnification of the boxed area of the corresponding upper panels. Arrowheads indicate ER. N, nucleus; G, secretory granules. B and C: Protein levels of ER chaperones GRP78, GRP94, calnexin (CNX), and calreticulin (CRT) were examined in whole pancreas (B) and isolated islets of Langerhans (C) from Grp78+/+ and +/− mice after 20 weeks of HFD (n ≥ 3 for each genotype) by Western blotting. Left panels: representative blots. Right panels: quantitative levels normalized against β-actin. Data are presented as the mean ± SEM. **P < 0.01.