Figure 6.
Differential cell death in exocrine pancreas of Grp78+/− mice with experimental pancreatitis. The Grp78+/+ and +/− mice were fed with either RD or HFD and treated with either PBS or cerulein as indicated. A: TUNEL assay on pancreas sections. Representative fields showing TUNEL signal alone (upper panels) or merged with DAPI (lower panels). B: Apoptotic cells (TUNEL merged with DAPI) were counted as percentage of total cells (DAPI). C: Necrotic cells were counted on H&E-stained pancreas sections as percentage of total cells. Data are presented as the mean ± SEM. n ≥ 3 mice for each condition. **P < 0.01.