Table 2.

Baseline, Week 5 and Week 10 Scores on key outcome measures ^‡

	Behavioral Intervention (N=61)		Education and Support (N=65)		Group Difference at Week 10
	Mean	95%CI	Mean	95%CI	95%CI	Effect Size*
Yale Global Tic Severity Scale
Total Tic Score
Baseline	24.7	(23.1,26.3)	24.6	(23.2,26.0)
Week 5	19.7	(17.6,21.7)	22.8	(20.7,24.9)	3.3 (5.4,1.2)	0.54
Week 10	17.1	(15.1,19.1)	21.1	(19.2,23.0)	4.1 (6.2,2.0)	0.68
Total Motor
Baseline	14.6	(13.5,15.7)	14.6	(13.8,15.4)
Week 5	12.2	(10.8,13.6)	13.6	(12.4,14.7)	1.3 (2.7,0.1)	0.34
Week 10	10.7	(9.3,12.1)	12.5	(11.5,13.5)	1.9 (3.3,0.4)	0.49
Total Vocal
Baseline	10.1	(9.0,11.2)	10.0	(8.9,11.1)
Week 5	7.4	(6.2,8.6)	9.3	(7.9,10.6)	2.0 (3.3,0.7)	0.43
Week 10	6.5	(5.4,7.6)	8.6	(7.4,9.8)	2.2 (3.6,0.9)	0.50
Impairment
Baseline	25.0	(22.6,27.4)	23.4	(21.6,25.2)
Week 5	16.8	(14.0,19.5)	20.1	(17.6,22.7)	3.8 (6.8,0.7)	0.47
Week 10	12.2	(9.8,14.6)	16.4	(13.8,19.0)	4.7 (7.8,1.6)	0.57
Parent Tic Questionnaire Total Score
Baseline	34.2	(29.5,38.9)	35.7	(30.3,41.1)
Week 5	25.8	(21.5,30.1)	33.7	(27.8,39.6)	7.3 (13.1,1.5)	0.28
Week 10	20.0	(16.3,23.7)	27.6	(23.0,32.2)	7.8 (13.8,1.9)	0.30
Children’s Global Assessment Scale *
Baseline	59.0	(57.1,60.9)	59.3	(57.3,61.3)
Week 10	69.4	(66.9,71.9)	64.1	(59.5,68.7)	5.8 (2.8,8.8)	0.64

^‡Data are presented as least square mean values and 95% confidence intervals for each assessment point. Group differences with 95% confidence intervals are also presented

^*Effect sizes were calculated as follows: change from baseline in behavior therapy minus change in the control group divided by the pooled standard deviation for the entire study sample at baseline.

^*Children’s Global Assessment Scale only administered at Baseline and Week 10