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A and B: Disease incidence in NOD-Alox15null mice compared with NOD mice. A: Females, n = 40; B: males, n = 34. Filled symbols: NOD-Alox15null; open symbols: NOD. C and D: Confirmation of 12/15-LO functional deletion. Comparison of expression of 12/15-LO in peritoneal exudate macrophages from NOD and NOD-Alox15null mice. Immunoblot (C) and real-time quantitative RT-PCR (D).
