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Schematic representation of the factor (F)V B-domain. The B-domain is defined by residues 710–1545 which are liberated after thrombin-mediated proteolysis. An expanded view of the B-domain is indicated along with the sequence of the basic region (963–1008) implicated in preserving the FV procofactor state. Yellow circles, potential N-linked glycosylation sites; green box, 31X-9 amino acid tandem repeat region; red box, 2X-17 amino acid repeat region; blue box residues 963–1008.
