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. 2010 Oct 1;107(46):20003–20008. doi: 10.1073/pnas.1013754107

Fig. 4.

Fig. 4.

Activation of the intrinsic apoptotic pathway is enhanced in transformed cells cultured with tubacin in combination with SAHA or etoposide. (A) Western blot analysis showing PARP degradation in LNCaP cells cultured with tubacin, SAHA, or simultaneous culture with tubacin and SAHA and (B) simultaneous culture of and tubacin and etoposide for 48 h. GAPDH is shown as a loading control. (C) Effect of the pan-caspase inhibitor Z-VAD-fmk on cell viability following a 48-h culture with tubacin, SAHA, or simultaneous addition of tubacin and SAHA and (D) 48-h culture with tubacin, etoposide, or simultaneous addition of tubacin and etoposide with and without Z-VAD-fmk. Error bars represent the SD of data points generated from experiments, which were all done in triplicate.