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. 2010 Dec;38(12):2226–2231. doi: 10.1124/dmd.110.035253

Fig. 6.

Fig. 6.

The effect of the pretreatment of SF aqueous extract and its constituents on CYP3A activity in DPX2 cells. DPX2 cells were exposed to SF aqueous extract and its constituents (10 μM each) for 48 h. After the treatment, the culture medium containing SF aqueous extract or its constituents was withdrawn and changed to the medium containing 50 μM midazolam. Midazolam was used as a probe for CYP3A activity analysis. 1′-Hydroxymidazolam was analyzed by UPLC-TOFMS. CYP3A activity in the control group was set as 1. Rifampicin (10 μM) served as a positive control. All data are presented as means ± S.D. (n = 3; *, p < 0.05 versus control).