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Cellular thiopurine circulation. The figure shows schematically the “transport” of TGMP out of the cell by ABCC4, its hydrolysis by NT5E on the exterior of the cell to form thioguanine nucleosides, and the transport of those nucleosides back into the cell by SLC28/SLC29 nucleoside transporters. TXMP, thioxanthosine monophosphate.
