TABLE 1.

Thiopurine cytotoxicity and “pathway” gene expression: Correlations between thiopurine pathway gene expression and IC₅₀ values for 6-TG and 6-MP in 194 lymphoblastoid cell lines

Data for genes listed more than once represent results for different expression array probesets. Many genes had multiple probesets on the array. The data have been ordered by p values from lowest to highest.

Gene	Chr	Probe Sets	6-TG		6-MP
			p Value	Correlation	p Value	Spearman Correlation
TPMT	6	203672_x_at	0.003	0.211	0.248	0.083
NT5E	6	1553995_a_at	0.010	−0.186	0.009	−0.188
TPMT	6	203671_at	0.018	0.170	0.536	0.045
NT5E	6	203939_at	0.025	−0.161	0.016	−0.174
GART	21	210005_at	0.062	−0.134	0.130	−0.109
AOX1	2	205083_at	0.065	−0.133	0.268	−0.08
GART	21	217445_s_at	0.075	−0.128	0.957	−0.004
PPAT	4	209434_s_at	0.090	−0.122	0.869	−0.012
ABCC4	13	203196_at	0.081	0.126	0.364	0.066
IMPDH1	7	204169_at	0.115	−0.114	0.091	0.122
PRPS1	X	209440_at	0.144	−0.105	0.490	0.05
HPRT1	X	202854_at	0.127	0.110	0.328	0.071
GART	21	212379_at	0.203	−0.092	0.260	0.081
ADK	10	204119_s_at	0.207	−0.091	0.177	−0.097
ABCC5	3	226363_at	0.308	−0.074	0.930	−0.006
ADA	20	204639_at	0.383	−0.063	0.483	−0.051
ADA	20	216705_s_at	0.384	−0.063	0.494	−0.049
XDH	2	210301_at	0.433	−0.057	0.920	0.007
PPAT	4	209433_s_at	0.523	−0.046	0.386	−0.063
GMPS	3	214431_at	0.499	0.0490	0.058	0.136
IMPDH2	3	201892_s_at	0.620	−0.036	0.145	0.105
AOX1	2	205082_s_at	0.611	−0.037	0.926	0.007
ABCC4	13	1555039_a_at	0.731	0.0250	0.864	−0.012
SLC29A1	6	201802_at	0.604	−0.037	0.581	0.039
SLC29A1	6	201801_s_at	0.697	0.028	0.454	0.054
GART	21	216990_at	0.727	0.0250	0.165	0.1
GART	21	212378_at	0.808	−0.018	0.175	0.098
ITPA	20	209171_at	0.761	−0.022	0.662	0.032
ADK	10	204120_s_at	0.829	−0.016	0.284	−0.077
AHCY	20	200903_s_at	0.803	−0.018	0.086	0.124
ABCC4	13	1554918_a_at	0.839	0.015	0.279	−0.078
ABCC5	3	209380_s_at	0.937	0.006	0.096	0.12